They argue that the slope of a linear or linearized exposure-response curve may be derived from studies in which past exposures, typically in the occupational environment, have been underestimated: they were in fact higher than estimated through present day reconstruction.
Second, the "heterogeneity in the population" argument states that variations in sensitivity among members ofthe target population tend to "flatten out and linearize" the exposure-response curve, but this actually only tends to broaden, not linearize, the dose-response relationship.
The general structure of the predicted D. geothermalis genome was tested by pulsed field gel electrophoresis (PFGE) of genomic DNA linearized in vivo by exposure to IR (0.2 kGy), and by restriction endonuclease (SpeI) cleavage (Figure 1C).
Although exposure measurement error may not always be large enough to appear to linearize a truly threshold dose-response relationship, it is important to bear in mind that this bias exists and that, in simulations, the degree of bias known to apply to actual studies is sufficient to produce a false, apparently linear exposure-excess risk result.
When the angular trajectories during the exposure time (tau =,4) ms were linearized by the least squares method, Fig. 8 shows the relationship between their inclinations and the input voltages to the piezo stages.
For genotoxic chemicals that lead to tumors by mutations of the DNA, it is generally accepted that a threshold cannot be defined and linearized mathematical models are used to define an exposure with acceptable risk as regards socioeconomic considerations.
linearized Boltzmann transport equation.
Resulted nonlinear model is linearized.
The model is then linearized.
linearized alternating direction method with adaptive penalty.
Now the system is linearized using Mathematica.
