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The design of a first linear prototype is supported by analytic and numerical analyses (CFD).
Cyclic analogues 3 and 4 were more resistant to proteases than was the linear prototype.
The LIPAc is a 9 MeV, D+ linear prototype accelerator for the validation of the IFMIF accelerator design.
This paper discloses a hydraulic solution implemented in a two stage linear prototype, where the volume, the flow rate and the coolant velocity can be controlled.
The operational simulation of passive prototypes in log-domain is feasible either by means of state-space-based techniques or by transforming the SFG corresponding to the linear prototype.
A series of 9-mer and 13-mer amide-bridged cyclic peptides derived from the linear prototype Ac-PKIIQSVGIS-Nle-K-Nle-NH2 (Toro et al. ChemBioChem 2013) has been designed and synthesized by introduction of the lactam between amino acid side chains that are separated by one helical turn (i, i+4).
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A review of the latest and most significant alternative linear prototypes is carried out, providing design concepts and performance characteristics.
Constrained pyrrolidine analogues that mimicked the bound conformation of linear prototypes were identified and investigated by co-crystal structure determinations with the related protein PKA.
Together with the Engineering Design Activities, prototyping sub-projects are pursued in the Engineering Validation Activities which consist of the design, manufacturing and testing of the following prototypical systems: Linear IFMIF Prototype Accelerator (LIPAc), EVEDA Lithium Test Loop (ELTL), and High Flux Test Module (HFTM) with the prototypical helium cooling loop (HELOKA).
The linear IFMIF prototype accelerator (LIPAc) produces deuteron beam with 1 MW power.
The concept is demonstrated in this paper with a linear programming prototype developed for a petroleum refinery.
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