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Endorse linear pathways to Nirvana.
They do not follow linear pathways or respond readily to the appliance of science.
Almost all pathfinding algorithms are limited to producing linear pathways with a few exceptions [41, 69].
Though linear pathways are sufficient in most cases, the capability of identifying more complex and efficient pathways would be desirable.
Here, we present an easy-to-use, purely data-driven approach, defining pool efflux capacities (PEC) for identifying reactions that exert the highest flux control in linear pathways.
C48 is not only strong and hard in 3D but also has unexpected 1D conduction along eight divided linear pathways in the unit cell.
GameInformer, GameSpot, and Game Trailers commented on the small world, with Game Trailers panning the linear pathways and "invisible walls" which prevent exploration along with the "cut and paste" dungeons.
These logical relationships extend the epistasis analysis beyond linear pathways to branched networks.
In cases where there are mostly linear pathways, as is believed to occur in some cancer cells, there is a greater potential for strong fluctuations in signaling statistics.
Our modeling approach thus represents a first step beyond the qualitative interpretation of linear pathways when the paucity of information precludes more detailed modeling.
In summary, this research formalizes and extends classical epistasis analysis from linear pathways to more complex networks, facilitating computational analysis and reconstruction of signaling arrow diagrams.
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