These results reveal a linear pathway from Nodal inducing mesodermal gene expression to Toddler promoting mesodermal migration.
Even though we demonstrated here PIK3R1-FOXO3a-cMYC as critical axis regulated by miR-155, the functional interactions among these players can be more complicated than linear pathway.
We show that the contributions of the integrin LFA-1 and the chemokine receptor CCR7 are complementary rather than positioned in a linear pathway, as they are during leukocyte extravasation from the blood vasculature.
First, we found that flp-7 npr-22 double mutants suppressed 5-HT-induced flp-7 npr-22the same extent as either single mutant alone with no adoublee effects, suggesting that they function in a single linear pathway (Fig. 8a).
Beetle movement tended to be more linear (pathway fractal dimension approached 1) on prairie dog habitats and more sinuous on adjacent grasslands.
On the other hand, for a linear pathway, proximity channeling is more beneficial when the constituting enzymes have relatively low activities and expression levels.
No longer is your career a linear pathway to success.
Therefore, the linear pathway is also supposed to be feasible.
Drugs inhibiting parts of the same linear pathway may act according to Loewe additivity [17].
There is no single, linear pathway linking CA and improvements in women's status.
To assemble the linear pathway in vivo, NAD+-dependent MDH from Bacillus methanolicus and artificial FLS were overexpressed in E. coli.
