Sentence examples for linear linkages from inspiring English sources

Whether CYLD also cleaves linear linkages in TNF-RSC I, and how this impacts the TNF signalling output, is currently unclear.

A DUB that exclusively cleaves linear linkages was also recently discovered; due to this activity, it was named OTULIN (also known as Gumby or Fam105B) 56, 56.

Apart from being a substrate of linear ubiquitination, NEMO was shown to bind linear linkages with 100-fold higher affinity than K63-linkages through its UBAN domain 41, 136, 137, suggesting that LUBAC, once recruited, orchestrates the sequence of events by enabling recruitment of NEMO via linear linkages on TNF RSC I components, like RIP1 and possibly others.

In addition, a donor ubiquitin can also be attached to an acceptor ubiquitin via the amino terminal methionine (M1) resulting in the formation of M1- or linear linkages, making a total of eight different inter-ubiquitin linkage types 5.

Third, apart from linear linkages, K11-, K48- and K63-linkages were found to be simultaneously present on RIP1 in TNF-RSC I, proposing that additional linkage types are required to orchestrate and modulate TNF's signalling output 24, 25 (Fig 3).

We used GenBank sequence information and the follow-up verification experiments to evaluate the predicted neighbours and thereby assessed the reliability of whole-genome microarray screening experiments in establishing linear linkages of defined sequence markers.

His dissertation established the principle of the linear linkage of genes in heredity.

The amounts of linkage between a series of genes can be combined to form a linear linkage map that roughly describes the arrangement of the genes along the chromosome.

The initial concentration of the intermediate linear linkage group Starchdb_CS was set to zero in all calculations.

Glutathione along with tocopherols were in linear linkage with antioxidant capacity, while inverse association with that of oxidative damage.

Having established FAM105B as a Met1-linkage-specific OTU DUB, we named the enzyme OTULIN (OTU DUB with linear linkage specificity).