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His dissertation established the principle of the linear linkage of genes in heredity.
The amounts of linkage between a series of genes can be combined to form a linear linkage map that roughly describes the arrangement of the genes along the chromosome.
The initial concentration of the intermediate linear linkage group Starchdb_CS was set to zero in all calculations.
Glutathione along with tocopherols were in linear linkage with antioxidant capacity, while inverse association with that of oxidative damage.
The aggregate pool of linear linkage groups released from solubilized starch by the action of the debranching enzyme is assigned the abbreviation Starchdb_CS.
Having established FAM105B as a Met1-linkage-specific OTU DUB, we named the enzyme OTULIN (OTU DUB with linear linkage specificity).
Similar(51)
For detection of linear-specific ubiquitination of RIP1 within the necrosome, the immunoprecipitated endogenous caspase-8 complexes were washed in lysis buffer and then disrupted in 6 M urea containing buffer and reimmunoprecipitated with linear linkage-specific anti-ubiquitin antibody as described previously.
Glycogen is a complex branched polymer of glucose, with α- 1,4) linear linkages and α- 1,4) branching lineares and a broad distribution of molinkagesweights, ∼10–10 Dand
A DUB that exclusively cleaves linear linkages was also recently discovered; due to this activity, it was named OTULIN (also known as Gumby or Fam105B) 56, 56.
CYLD, a DUB that can cleave both K63- and linear linkages, was shown to negatively regulate NF-κB activation by removing K63 linkages from RIP1 139, 140, 141, 142.
Whether CYLD also cleaves linear linkages in TNF-RSC I, and how this impacts the TNF signalling output, is currently unclear.
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