Exact(26)
The stopping rules for certain iterative methods designed for solving linear equations and a linear elimination problem are proposed and analysed.
A one-compartment open model with linear elimination adequately described the Ep time courses.
The slope of the log linear (elimination) phase (k ′∞) was estimated between 72 and 168 h.
A one-compartment open model with linear elimination adequately described the Ep concentration-time courses.
A two-compartment open model with first-order lagged absorption and linear elimination best described the PK data.
In conclusion, serum concentrations of HuHMFG1 can be successfully described using a two-compartmental model with linear elimination.
Similar(34)
A non-linear elimination of the Db, implicating various factors, remains to be proved.
Several models were investigated: one-, two- or three-compartmental linear models, with or without additional non-linear elimination.
The k-values represent linear distribution- and elimination rate constants, and the Vmax and Km values represent Michaelis Menten constants for non-linear elimination from the first compartment.
Other models tested (one- or three-compartmental models) with non-linear or combined (linear and non-linear) elimination were more complex and did not lead to improved results.
The non-linear elimination pathway presumably involves the binding of MEDI-546 to IFNAR and the subsequent internalization and intracellular degradation of the antibody-receptor complex.
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