Sentence examples for linear disposition from inspiring English sources

Because of its assumption of linear disposition, the non-compartmental analysis (NCA) method is inappropriate for PK analysis of drugs with TMDD, except perhaps for initial exploration to uncover or confirm TMDD.

A two-compartment linear disposition model was used.

A one-compartment linear disposition model was used to fit data to the PK model.

A one-compartment linear disposition model was used to fit data.

As explained in the result section, our simulations assumed a linear disposition of cimicoxib.

In contrast, docetaxel has a linear disposition over the dose ranges used clinically, so its concentration changes linearly with changes in the dosage.

This non-linearity may arise from the non-linear disposition of a drug as well as the saturation of metabolic enzymes or drug transporters [ 32, 33].

The kinetics of drug disposition is described as a non-linear disposition function of drug structure and properties.

From the terminal log-linear (disposition) phase, a first order elimination rate constant (λz) was estimated by linear regression and terminal half-life value (t½) was estimated from at least three concentration values using the equation (t½) = ln2 / λz.

For all analytes the AUC was estimated from the start of infusion by the logarithmic-linear trapezoidal rule and extrapolated to infinity using the estimated value of the slope of the terminal logarithmic-linear disposition phase.

The apparent terminal elimination rate constant (λz) was derived from the log-linear disposition phase of the concentration time curve using least squares regression analysis, with visual inspection of the data to determine the appropriate number of data points to include in the calculation of λz.