Sentence examples for linear determinants from inspiring English sources

The analysis of HIV antibody data documents that the linear determinants recognized by human or murine humoral immune responses, are (or harbor) pentapeptide fragments with no or only very low similarity to the respective host proteome.

Regarding VHSV G, the presence in its sequence of linear determinants that activate the type I IFN system has been reported (VHSV G Mx-inducing peptides).

Pepscan mapping of autophagy-inducing linear determinants of Gvhsv and Gvsv showed that peptides located in their fusion domains induce autophagy.

This well-defined system highlights the different challenges between rendering a linear determinant (here) immunogenic, compared to applying this approach to a more complex conformational determinant such as the CD4 binding site of gp120 (recognized by the broadly neutralizing antibodies b12 and VRC01).

A multi-epitope-vaccine MEVABC consisting of two linear neutralizing determinants (BC1: aa693–716; A6: aa844–865) located on antigenic unit B/C and unit A of glycoprotein E2 was prepared to evaluate whether a combination strategy is effective in the design of peptide vaccines.

However, only few linear immunogenic determinants on the surface of the virion of each dengue serotype have been identified and a detailed map of the dengue linear B-cell epitopes still need to be determined [14].

One of the first conserved linear neutralizing determinants to be described was the region of E2 encompassing aa 412 423, that is targeted by murine AP33 (Owsianka et al., 2005) and 3/11 (Flint et al., 1999b) and human monoclonal antibodies HCV1 (Broering et al., 2009) and HC33 (Keck et al., 2013)).

In part, this might require the optimization of conformational fixation, while at the same time maintaining immunogenicity of the linear 2F5 epitope determinant.

A major linear antigenic determinant of the Erns protein could be identified by epitope mapping with a polyclonal anti-Erns serum.

Using an in vivo mapping strategy employing peptide immunogens and an optimized in vitro toxin neutralization assay, we identified a linear neutralizing determinant in the N-terminal 19 amino acids of alpha hemolysin.

Thus, Equations (1) and (2) define generalised linear models for determinants of human rights with binomial response and logit link [ 43, 44].