When facilities were operating in 1987 and 1995, we assumed a linear change between 1987 and 1995, with stable emission levels before 1987 and after 1995.
In the fourth trial, which was 28 weeks in duration [ 6], 24-week scores were imputed based on the assumption of linear change between Week 28 and the most recent prior visit.
In the first sensitivity scenario QALYs were calculated by integrating utility values over time (area under the curve), based on EQ-5D values at baseline and three months, and assuming a linear change between measurements [ 30].
Percentage time in range was calculated according to Rosendaal's equation [ 27] which assumes a linear change between INR results through a specific software programme (BAP-PC, Birmingham University).
Based on estimates for the Holstein cattle population [ 29], the Ne was set to 100 in the final generation of simulation and to 1256, 4350, and 43 500 at 1000, 10 000, and 100 000 generations ago, with linear changes in between.
The reduction of Ne in the preceding generations was modeled with a Ne 1000 years ago of 1256, a Ne 10,000 years ago of 4350, and a Ne 100,000 years ago of 43,500 with linear changes in between.
Based on estimates for the Holstein cattle population [ 23], effective population size was set to N e = 100 in the final generation of simulation, to N e = 1256 for 1000 years ago, to N e = 4350 for 10 000 years ago, and to N e = 43 500 for 100 000 years ago, with linear changes in between.
Median length of an SH episode, assuming linear changes of glucose values between measurements, was 20 (10 to 50) minutes.
The results indicated that there was a significant decrease of warpage and linear dimensional changes between PMMA specimens and that of PMMA MMT composite materials.
We used a formula that, for practical reasons, assumed a linear change over time between measurements.
