Sentence examples for lineage survival from inspiring English sources

Garraway, L.A. et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.

SOX2 and its associated proteins (e.g., ΔNP63α), which regulate lineage survival of ESCC cells, are proposed as therapeutic targets.

But suppose we turn the relation between reproduction and survival on its head and think of reproduction as important only insofar as it contributes to lineage survival.

MiTF is a transcription factor required for melanocyte lineage survival and melanin production; MiTF is also implicated in melanoma progression and metastasis [52], [53], [54].

Continued expression of MITF has been shown to be essential for melanoma cell proliferation and survival and, in fact, MITF has been proposed to act as a lineage survival oncogene in melanoma [23].

As MITF is a lineage survival oncogene in melanoma [23] whose expression needs to be maintained at a certain level, it is likely that these miRNAs play an important role in regulating MITF mRNA levels in this cell type.

It is believed that targeting the lineage-survival mechanism may be more effective than targeting other mechanisms.

Moreover, the developmental transcription factor Thyroid transcriptional factor 1 (TITF1) has been shown to be a lineage-survival oncogene over-expressed and amplified in lung adenocarcinoma development [6].

Sox2 is a lineage-survival oncogene in lung and esophageal squamous cell carcinomas [47].

This suggests a role for Sox2 as a lineage-survival oncogene rather than as a stemness marker [ 60].

High levels of SOX9 expression in MPNSTs appear to result in SOX9 'addiction', consistent with SOX9 being a lineage-survival oncogene in this system (Garraway & Sellers, 2006).