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The increased number of alternative promoters from a single locus will provide increased flexibility and diversity of AP usage, and thereby generate either identical or distinct protein conducts in a tissues, cell lineage, stage, and time point specific manner.
Although enrichment of DCs in RA synovial tissue and fluid and in seronegative synovial fluid has been reported [ 20- 26], the considerable phenotypic, morphologic and functional variations between DC subsets related to lineage, stage of maturation and tissue localisation remains less well understood.
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15 Thus, expansion and survival conditions are lineage stage-specific in terms of matrix and soluble signals, a finding similar to that reported previously for human parenchymal cells.
Why was the analysis done so late (P40) since other lineage stages might have been missed?
(A ) Diagram of stages of stomatal development (abbreviated as in Figure 1A ) and expression window of signaling and polarity regulators indicated as bars spanning lineage stages.
Indeed, tumor cells appear to progress through lineage stages like those of normal tissues, being their division auto-regulated by internal feedback mechanisms.
An important aspect of colon crypt development and formation is its spatial patterning of cells at different lineage stages within intestinal tissues.
In our model tumor cells are assumed to progress through lineage stages like those of normal evolution, and a bounded cell division is introduced.
Effects of AHR activation have been evaluated on rodent hepatic stem cells (rHpSCs) versus their descendants, hepatoblasts (rHBs), two lineage stages of multipotent, hepatic precursors with overlapping but also distinct phenotypic traits.
Intracellular E-cadherin and ALB staining patterns provided a means by which to separate and rapidly quantify the two lineage stages using a combination of automated image acquisition, high-content imaging, and a gating strategy similar to that used in single-cell flow cytometric analyses.
10, 11 Lineage stages of hepatic parenchyma and their partner mesenchymal cells begin with biliary tree stem cells (BTSCs) in peribiliary glands (PBGs); transitioning to hepatic stem cells (HpSCs) and hepatoblasts (HBs) in/near canals of Hering; continuing to acinar plates of parenchymal cells; and ending with terminally differentiated cells pericentrally.
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