This function maps the individual cell lineage's rankings (lineage profiles) into a ranking of fates for the tissue (tissue profile).
Condition of unrestricted domain: It is required that whatever principle of going from individual lineage profiles to a collective tissue profile is discussed, the LTM must be free of contradiction and inconsistencies for any logically possible set of individual orderings (lineage profiles).
CONDITION 3 (independence of irrelevant alternatives): Let R and R' be the tissue binary relations determined by F corresponding respectively to two sets of individual lineage profiles, (R 1,..., R n) and (R 1 ', …, R n ' ).
To explore the combinatorial theme further, we next identified those transcription factors that share their expression profiles with 6 well-characterized transcription factors with distinct roles in the development of the 8 blood lineages profiled in this study.
Consequently, the lineage gene profile of MHCII-signalled 4in8 thymocytes (Zbtb7b lo Runx3+ Cd8b+) markedly differed from that of conventional MHCII-signalled B2m −/− thymocytes (Zbtb7b+ Runx3− Cd8b−), which differentiate into helper-lineage T cells.
However, the lineage gene profile of MHCII-signalled 4in8 thymocytes was nearly identical to that of conventional MHCI-signalled thymocytes (Zbtb7b − Runx3 + Cd8b + ), which depend on Cd8-encoded CD8 proteins and differentiate into cytotoxic-lineage T cells.
The problem can be seen as a model selection problem, where different comparisons are thought of as different model structures (H1,… H5) and, given experimental lineage commitment profile data D, the marginal likelihood P(D | Hj), j=1,…,5, is used to score different models.
Amongst the cultivars of cannabis the distinction of 3 varieties is a common way of describing the plant lineages and profile of effects.
Spline-based EDGE method by Storey et al. [ 12] is relevant for our problem because it provides comparisons for multiple conditions (lineage commitment profiles).
These similarities may be based on their shared cellular lineages, proteomic profiles, cellular polarity, and functionally analogous roles in the CNS [26], [27], [36], [37].
