Typically, GARD is run in a single-lineage mode, where at each split event only one progeny (picked at random) is followed and the other one is discarded [ 36].
A composome is defined as a set of subsequently faithfully replicating assemblies (a term originally derived from compositional genome), where a faithfully replicating assembly is defined as an assembly which is highly similar to its predecessor and successor, when GARD is run in single-lineage mode [ 36].
Relevant natural history factors include lineage, foraging mode [9] [13] and body size or body shape [9] [13], which in turn may also be influenced by the environment.
In contrast, analysis of cell type-specific proteomes highlight specialized biological functions that are associated with cell lineage and mode of culture, as will be discussed below.
The relatively low conservation of Made1 derived target sites is also consistent with this lineage-specific mode of evolution.
The first is the lineage-based mode, which depends on factors transmitted from progenitor to daughter cells.
Conclusion: Our findings are consistent with a lineage-dependent mode of action for AHR agonists in rodent liver tumorigenesis through selective expansion of rHpSCs in combination with a toxicity-induced loss of viability of rHBs.
Within lineage 1, the mode of G1 fluorescence signal of VIB was 0.27 rfu and was significantly different from all other isolates, with a nearly two-fold increase in fluorescence intensity at both G1 and G2 peaks (p<0.05).
The U lineage displays two modes of evolution, most pronouncedly observed in classical-type alpha 1 domains; cod and stickleback have expanded on one of at least eight ancient alpha 1 domain lineages as opposed to many other teleosts that preserved a number of these ancient lineages.
Since the generation and maintenance of most cellular patterns may depend on the interplay among gradients, cellular communication, environmental signals and lineage-related mechanisms, the intrinsic vs. extrinsic distinction that could be identified with lineage vs. positional modes of fate determination is sometimes blurred (see more examples of this claim in [ 3]).
