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The pufferfish lineage lost three genes in the common lineage leading to Takifugu and Tetraodon.
With respect to green algae this means one lineage lost its nucleomorph and one retained it.
This result is consistent with a CM dedifferentiation process, in which CMs, originating from the Myh6 lineage, lost cTnT expression.
Their results also implied that the GLO1 lineage has been lost from the Gentianales and the GLO2 lineage lost from the Lamiales.
Following the latter split, the Tsukubamonas lineage lost only six additional protein-coding genes, similar to the ancestral lineage of Acrasis + Naegleria, which lost five protein-coding genes.
After differentiation into glial lineage, neuronal markers were lost, while cells that differentiated into neuronal lineage, lost glial markers [ 5, 6].
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This is illustrated in Fig. 5c in which an originally striped fish lineage loses its stripes and then regains them, producing a species similar to a closely related lineage that never lost its stripes in the first place.
Those DN3 cells that successfully rearrange their β chain and therefore commit to the TCR αβ lineage lose expression of CD25 halt proliferation and enter the final phase of their DN stage of development, DN4 (c-kitlow/− CD44− CD25−), which maturate directly into DP thymocytes [ 5, 8].
Later, after the split of the major vertebrate lineages, some lineages lost the paralog that had no AS (mammals) whereas other lineages lost one of the AS isoforms from the paralog that did have AS (fig. 3).
Analogously, we define the pairwise loss time distribution as the distribution of times when two independently evolving lineages lost their last common spacer.
A number of these secondarily phototrophic lineages lost their photosynthetic ability and further diverged into secondarily heterotrophic, plastid-lacking protists [ 2, 3].
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