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For example, introduction of wild-type (wt) p53 into undifferentiated early pre-B cell line, which lacks p53 induced their differentiation [25], [26].
To explore if the Unc119 mediated regulation of bacterial infection is dependent upon SFKs, we used the SFK deficient SYF fibroblast cell line, which lacks Src, Yes and Fyn kinases.
To test the hypothesis that a transient reduction in gene expression can initiate epigenetic silencing, we used the tet-off system [24] to control transcription levels of human HPRT cDNA in the mouse Dif-6 cell line, which lacks expression of endogenous Hprt [25].
We used for these experiments a transgenic P. falciparum line, which lacks the osmiophilic body-specific protein Pfg377.
Along the lateral sides of each juvenile tentacle, the thin line, which lacks of epidermis, extends (Fig. 6b, d).
She et al (2003) reported that the MDA468 breast cancer cell line, which lacks PTEN function, was resistant to gefitinib.
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H460 cells were used as another control cell line, which lacked methylation of both genes, and HUVECs were used as a control cell line to test the effects of anti-VEGF/VEGFR drugs on proliferation.
This experimental setup allowed us to bolster our findings in HCT116 cells and test the effect of NDI1 expression in a human cell line which lacked endogenous complex I activity.
7 d) and (e), prostate cancer cell lines DU-145, PC-3 (which have constitutively activated NF-κB pathway) and non-small-cell lung cancer (NSCLC) cell line A549 (which has constitutively activated STAT3 pathway) cells are significantly more sensitive than H460 cells (NSCLC cell line which lacked constitutively activated NF-κB or STAT3 pathway) to growth inhibition of 2-MS.
No abscission event occurred in the def mutant lines which lacked the double palisade in the hilum region.
The BT549 and MDA-MB-231 cell lines are triple negative breast cancer (TNBC) cell lines, which lack expression of estrogen receptor alpha (ESR1), progesterone receptors, and HER2/neu.
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