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Furthermore, the same cell line, when exposed to monomeric Aβ or γ-secretase inhibitors, exhibited an increase in the number of tip cells and branches [ 63].
Several stress-related metabolites, remarkably raffinose, were altered in content in the H. chilense alloplasmic line when exposed to high light, while amino acids, as well as organic acids were significantly decreased.
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The GI50 for both cancer cell lines when exposed to BioEG was also determined and compared to the results obtained with surfactin.
The concentration of lactate in both PC12 and B12 parental lines decreased with exposure to Aβ whereas the concentration of lactate was maintained or increased in all the resistant lines when exposed to Aβ for 24 or 48 hrs.
We further plan to study the integrity of Y chromosome in cell lines when exposed to arsenic.
The proficient DNA damage repair capability of cancer cell lines when exposed to ionizing radiation and chemotherapeutic agents has been shown to correlate with treatment resistance [ 34, 35].
We found down-regulation of cell cycle molecules including CDC25A, DNA replication genes including the minichromosome maintenance proteins (MCMs) and pyrimidine metabolism genes in both cell lines when exposed to hypoxia.
Furthermore, we found that the expression of MICA/B was upregulated, while there were no significant changes in expression of HLA-ABC in the two HCC cell lines when exposed to SAHA.
Experiments were conducted to determine if the synergy observed in cultured cell lines when exposed simultaneously to gemcitabine and troxacitabine also occurred in an in vivo human xenograft model of AsPC-1 cells in SCID mice.
The same aneuploid lines when exposed to an external solution containing 200 mM NaCl and 4 mM K+ showed no differences in K+ concentration in bulked leaf blades regardless of the genotype or the Na+ status.
It must be pointed out that all cell lines, when exposed to MI-D at 10 μ or more, did not grow and extensive cell death was observed, confirming the previous data appearing in Figure 2. Figure 4 shows the effects of MI-D on MEL-85 adhesion to extracellular matrix (ECM) constituents, such as laminin, fibronectin and matrigel.
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