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In one patient and one cell line we observed more than one mutation in the p53 coding sequence.
In line, we observed immediately upon ischemia strongly elevated arteriovenous concentration gradients of I-FABP, reflecting the membrane integrity loss of the epithelial cells of the villus.
Among all three quiescent primary human tissues and the proliferating HepG2 carcinoma line, we observed overlap greater than 70% and as high as 84% (Figure 2A, Figure S2).
A specific example is that in clinical specimens (and xenografts of one cell line) we observed a correlation between hypoxia and chromograinin A expression but exposure to cell lines to anoxia in vitro did not result in increased expression.
Similar to the Plp-Cre Rosa26LacZ Plp-Cre Rosa26LacZline, we observedouble levels of EGFP expression transgenic CNS tissues occurring outside of olinedendrocyte-rich regions (Fig. 8B, C, D).
When c-Myb protein levels were significantly decreased relative to the parental cell line, we observed faster cell growth, increased tamoxifen resistance, and increased colony formation in vitro (Figs. 3B C, Table 1).
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Moreover, upon prolonged culture of CSES1 cell line, we observe partial reactivation of the second allele that coincides with the loss of XIST expression at later passages.
Using human melanoma cell lines, we observed that cell adhesion was minimally affected by BRAF inhibition but ablated by ERK inhibition.
When we performed a similar staining comparison in THP-1 and Jurkat cell lines, we observed relatively smaller increases in BST-2 expression upon permeabilization of the cells (Fig. 3C and D).
After genetic impairment of autophagy (via atg5 or atg9 KD) using two different MB-specific Gal4-driver lines, we observed the presynaptic metaplasticity across the Drosophila olfactory system and beyond.
Despite significant differences in infectious virus titers between the two mouse lines, we observed similar levels of inflammation and apoptosis in spleen and liver, although the two lines displayed distinct histopathology (figs. S4 to S6).
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