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When examining MMS sensitivity, the current mouse pol λ −/− cell line was not substantially more sensitive to MMS than the wild-type cell line except at the highest dose tested, whereas the pol β −/− cell line was hypersensitive to MMS treatment.
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However, primary root growth and germination of ABACUS1 lines was hypersensitive to inhibition by exogenous ABA, and hypersensitivity correlated with the affinity of the PYL1 domain of the biosensors.
Furthermore, root elongation in the 35S:: GbRLK transgenic lines was hypersensitive to ABA (data not shown).
Thus, postgermination growth of the AtERF13 OX lines was hypersensitive to ABA.
Arabidopsis CPK12-RNAi lines were hypersensitive to ABA during seed germination and root elongation [ 21].
Additionally, the AtERF13 OX lines were hypersensitive to glucose, whose effect is mediated by ABA.
Thus, our results indicated that AtERF13 OX lines are hypersensitive to glucose.
Subgroup #1 cell lines were hypersensitive to etoposide, a potent and specific inducer of dsDNA breaks [ 23].
We did not observe changes in ABA sensitivity; however, similar to RAP2.4L OX lines, the RAP2.4 OX lines were hypersensitive to glucose.
Moreover, sod-1 OE lines were hypersensitive rather than resistant to oxidative stress, hinting that SOD OE might not reduce ROS-induced damage in these strains.
Ku80-deficient ES cells and pre-B-cell lines are hypersensitive to IR (Nussenzweig et al, 1997) and consistent with the radiation-hypersensitive phenotype of the cell lines, Ku80 mutant mice also display extreme radiosensitivity (Nussenzweig et al, 1997).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com