However, warnings of possible hepatotoxicity were added to the US labelling in 2007, and in 2008, moxifloxacin was restricted to second line indications in Europe [ 72].
Enlarged with an on-line indication system, a cylinder pressure based engine management system can be established, where the desired control settings are calculated by an upper level engine optimization.
Accordingly, the second-line indication for pemetrexed was revised to include patients with advanced NSCLC of predominantly non-squamous histology only.
AFFINITY, which assesses the second-line indication comparing cabazitaxel with or without OGX-011 in post-docetaxel-treated CRPC, has completed enrolment and should read out by end of 2015 (Table 1).
With regard to the approval of thiazolidinediones, Europe evaluated these agents a little later and made approvals for second-line indication (unless metformin was not appropriate) and excluded New York Heart Association class I IV (vs. first-line approval and exclusion of New York Heart Association class III and IV by the FDA).
He also has the Conservative line, an indication that his politics are at odds with most voters in this district.
The excellent activity of anidulafungin has made this antifungal a first line therapeutic indication for candidemia and invasive candidiasis in non-neutropenic patients.
It was a big applause line, an indication that the Democrats, unlike those mudslinging Republicans, were going to keep their campaign arguments in the realm of policy, not personality.
Other large banks have also reported a decline in their top lines, an indication that, five years after the financial crisis, they are still struggling to expand their businesses.
A maximum roundtrip efficiency of 60% was obtained for the base case configuration assuming turbomachinery and heat exchanger performances in line with indications from manufacturers.
Huggins' observations, which revealed that the nebula's spectrum was non-continuous and made of a few bright emission lines, first indication that planetary nebulae consist of tenuous ionised gas.
