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The Scc1-deficient cell line exhibited increased chromosome aberrations in S/G2 and a reduced frequency of sister-chromatid exchange (SCE).
Among the 10 gastric cancer cell lines, only the GCIY cell line exhibited increased UNC5C mRNA expression levels (lowerΔCT, Fig. 3e).
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It has been shown that mammospheres of a tamoxifen-resistant MCF7 cell line exhibits increased breast cancer resistance protein (BCRP) levels in response to tamoxifen treatment.
Targeting sialophorin with siRNA resulted in the MCF7 breast cancer cell line exhibiting increased homotypic adhesion, decreased transendothelial migration, increased susceptibility to apoptosis, increased vulnerability to lysis by natural killer cells and decreased ability to produce tumours in mice.
Transgenic rice lines exhibited increased glyoxalase enzyme activity, decreased methylglyoxal level and improved tolerance to NaCl, ZnCl2 and mannitol compared to wild-type plants.
By contrast, the RNAi lines exhibited increased susceptibility to the fungal pathogen compared with the WT plants.
As a control, PC12 and B12 parental cells were exposed to hypoxic conditions (1% O2) for 24 hr, as hypoxia is a known activator of LDHA [16], revealing that both lines exhibited increased LDHA activity when exposed to hypoxic conditions.
The OsCPK9-OX rice lines exhibited increased sensitivity to ABA.
Most normal and cancer cell lines exhibited increased expression levels compared with LCLs.
These cell lines exhibited increased TGFβ activity, as measured by a luciferase reporter assay.
Both lines exhibited increased levels of C-circles, albeit to a different extent, suggesting persistent recombination activity in these animals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com