Sentence examples for line efficacy from inspiring English sources

Indeed, our data show that overexpression of NTR1s induce formation of additional clathrin coated pits, potentially explaining the receptor/cell line efficacy differences observed for β-arrestin activation by BG/MG.

Although single-agent bexarotene had modest growth inhibitory effects in several cell lines, efficacy was observed only in the micromolar range (>1 μM), which approximates the plasma Cmax measured in pharmacokinetic studies in patients.

The importance of first-line efficacy was demonstrated by PENPACT-1 trial data.

The reason for this potential correlation between previous treatment duration and second-line efficacy is not known.

Given the equivalent first-line efficacy of oxaliplatin and irinotecan regimens, the ability to predict toxicity would be of value in individualising treatment decisions.

Furthermore, sunitinib demonstrated superior first-line efficacy over IFN-α, with significantly greater progression-free survival (PFS) (Motzer et al, 2007, 2009).

Early studies in which irinotecan was combined or alternated with 5-FU/FA regimens showed promising first-line efficacy in advanced CRC [ 15- 19].

Different factors associated with second-line efficacy had been identified and were mainly adherence [ 20] or accumulation of mutations due to late diagnosis of failure [ 21].

Until recently, the only biological agent with proven first-line efficacy was bevacizumab, but options have expanded from the data generated with anti-EGFR monoclonal antibodies.

If the first-line efficacy of the platinum-based chemotherapy was good, a combination of cisplatin and cetuximab could be proposed after progression.

Comparison of oxaliplatin combined with an infusional 5-FU/FA regimen (FOLFOX) with irinotecan in combination with bolus 5-FU/FA (IFL) in the US intergroup study (Goldberg et al, 2004) suggested that the FOLFOX combination was superior in terms of first-line efficacy.