Exact(3)
However, based on our data we cannot fully rule out that reduced germ cell or GSC survival causes or contributes to the germ line depletion phenotype in cul-5 mutant ovaries.
In line, depletion of other ESCRT complex components produces a similar phenotype.
In the Ubl4A K48R cell line, depletion of USP13 still causes accumulation of ERAD substrate TCRα (data not shown).
Similar(57)
In both cell lines, depletion of 14-3-3τ 14-3-3τ 14-3-3τledels of Beclin 1.
Along similar lines, depletion of BMI1 caused a concomitant loss of MEL18 at the locus and vice versa (Fig. 6C and D).
In some cancer cell lines, depletion of TACC3 induces postmitotic cell cycle arrest or mitotic cell death.
In the majority of cell lines, depletion of GSH by >80% was not cytotoxic, whereas three cell lines were affected by BSO.
In both cell lines, depletion of XIAP significantly enhanced cell death after combination treatment with TRAIL and bortezomib at all concentrations tested.
In both human and murine pancreatic tumor cell lines, depletion of RAGE significantly increased sensitivity to hypoxia, to UV radiation and to cytotoxic chemotherapy, concomitantly with significantly increased induction of cleaved caspase-3.
Additionally, as was observed in the breast cancer lines, depletion of cellular ATP in each of the colon and thyroid cancer cell lines resulted in a time-dependent increase of nuclear PTEN protein (Fig. 2C and D, Supplementary Material, Fig. S1).
There are a number of lines of evidence for this; first (and most importantly) Seoane et al. have shown that in colorectal cancer cell lines depletion of C-MYC reduces apoptosis as a consequence of altering the balance of downstream effectors of P53 signalling.
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