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Finally, from our parentage analysis we found no significant differences in microsatellite heterozygosity between promiscuous line and monogamous line animals (data not shown).
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This is in line with animal data.
In line with animal data, this may include upregulation of classical BAT deposits versus the possibility that chronic glucagon receptor agonism may promote WAT transdifferentiation to a more brown-like phenotype.
Our data are in line with animal data and human neuroimaging studies providing evidence that the mPFC regulates the expression of fear and anxiety by inhibiting the amygdala (Milad & Quirk, 2002; Maren & Quirk, 2004; Sotres-Bayon et al., 2004; Milad et al., 2006).
Similar results were obtained in all other independent cell lines derived from PRLR KO animals (data not shown).
MPTP treatment also results in increased striatal dopamine turnover (DOPAC/DA) which is not statistically different in any of the transgenic lines compared to non-transgenic animals (data not shown).
The expression of p19ARF can not exclusively be attributed to lung infiltrating cells of the hematopoietic system since we do see pronounced p19ARF expression in AT2 cells and cells lining the bronchi in Bmi1−/− animals (data not shown).
The number of macrophages and neutrophils within the yolk sac lining the wall was increased compared with control animals (data not shown).
We did not find either neuronal loss or gliosis in the motor cortex and the basal ganglia of the BAC expansion lines (BAC-Exp1, BAC-Exp2 and BAC-Exp5) compared with nontransgenic animals (data not shown).
R26PR dLck-cre animals did not develop T-ALL; they weR26PR dLck-creshanimalsom control animals andidtill healthy at 8 monots (n=12 animals; developt shown), far beyond the latheyy observed from the other lines.
Our finding is also in line with some animal data.
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