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As with adaptation more broadly, there can be costs of and limits to adaptive phenotypic plasticity as well, including genetic costs and developmental range limits (DeWitt et al. 1998).
The complex phenotypes in hibernation are examples of extreme physiology that represent limits to adaptive design and are therefore intriguing to biologists.
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In certain studies however, the effector cells are not limited to the adaptive immunity.
The fact that leaders' greatest overestimations are limited to the adaptive leadership skills shows how tough these skills are to master and how few leaders have honed their skills adequately.
In contrast, by deterministically substituting only the largest beneficial mutations [22], [32], large populations will be limited to fewer adaptive routes that climb the nearest fitness peak with the steepest slope, but not necessarily the highest peak.
In contrast, traditional genomic scans for positive selection rely on the hitchhiking pattern evident in linked neutral variation (Maynard Smith and Haigh 1974) and are limited to detecting adaptive fixations having occurred within ∼0.2 2 Ne generations (Kim and Stephan 2002).
Moreover, classic MHC molecules are typically expressed at low levels in the CNS and though there clearly is continuous surveillance of the CNS by T cells, the low levels of T cells and limited MHC expression are likely to limit adaptive immune responses to misfolded self proteins in the CNS.
This study is the first large consecutive series of implanted rhesus macaque to be studied longitudinally using brief stimuli designed to limit adaptive changes in response, so that the efficacy of electrical activation can be studied over time, across surgeries, canals and animals.
SOCS2 limits adaptive anti-tumoral immunity and DC-based priming of T cells in vivo, indicating a critical regulatory role.
Future experimental studies will show whether larger GS in Knautia limits adaptive and competitive abilities of populations [ 76] at the genus' distribution margins and might thus represent a factor limiting further range expansion.
This parallels wider work on household decision-making in development studies that highlights how constrained access to livelihood assets limits the adaptive choices available to people in response to shocks and stresses (e.g. Ellis 2000; McDowell and Hess 2012).
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