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48, 51 These observations strongly suggest that, in steady-state hematopoiesis, TET2 limits the function of HSCs such as self-renewal and LTR capacities, and functional disruption of TET2 either by gene-targeting or disease-associated mutations would lead to aberrantly elevated HSC capacities and subsequent amplification of multipotent progenitor/CMP fraction.
ABCLibScript limits the function of auto-tuning to numerical computations.
This situation limits the function of public parks as social integrators.
If a painful pseudo-arthrosis limits the function of a shoulder, fractured ends should be fixed until union occurs.
"This is the largest disincentive for electric vehicles since it limits the function and usefulness of the vehicle and may require the purchase of a traditional gas vehicle to compensate for the lack of capability".
Hence, Pol δ-PCNA does not function with CMG and severely competes and limits the function of Pol α with CMG.
Similar(52)
How do we explain that short telomeres limit the function of tissues of slow turnover?
In general, the influence of different immunosuppressive drugs on NK cell function is of particular interest as it has recently been demonstrated that steroids and calcineurin inhibitors limit the function of IL-2-activated NK cells [28], [29].
Another mechanism limiting the function of transplanted cells for cartilage repair is aging or senescence.
However, one could also speculate that the normal endogenous levels of NAD+ limit the function of SIR-2.1.
Retinal haemorrhages, for example, could limit the function of the visual pathway and thus affect the normal development of visual function.
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