Exact(4)
The major limitation is the cross-sectional nature of the study design that limits the determination of temporal relationships.
In addition, the cross-sectional design of our study limits the determination of causal associations between the study variables.
The extremely low frequency of the mutation limits the determination of an association to overweight and obesity (p = 1; Table 2).
The vast difference in the abundance of different proteins in biological samples limits the determination of the complete proteome of a cell type, requiring fractionation of proteins and peptides before MS analysis.
Similar(56)
However, our data showing a significant correlation between platelet count and Ang-1 levels only in patients with severe thrombocytopenia, but not in patients with higher and more variable platelet counts, suggest that severe hypoplastic thrombocytopenia could attenuate the influence of the pre-analytical variables that normally limit the determination of "true" Ang-1 levels.
However, it is important to note that other malignancies than HCC occurred rarely in our cohort, which limits the exact determination of sensitivity/specificity for detecting malignancies other than HCC for the tumor markers investigated.
Consequently, their measurements were limited to the determination of transmittance, reflectance, and absorbance of the PCM.
Identification was limited to the determination of the subsoil's modulus of elasticity.
Existing data are limited for the determination of the impact of PET in certain malignancies, and further studies, which should include outcome information, will allow clarification of the role of this modality for such indications.
Investigation of lactate metabolism at the bedside is limited to the determination of its concentration.
In such cases, method validation could be limited to the determination of repeatability, linearity and specificity.
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