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Our in vitro data indicated that excessive ROS not only limits survival of virus-specific T cells but may also affect T-cell function.
These data indicate that loss of H+ efflux limits survival of cells containing multiple oncogenic lesions and suggest a broad applicability of limiting H+ efflux to increase cell death across cancer types.
These data imply that wild-type p53 limits survival of ErbB2-overexpressing breast cancer cells, and suggest that signals of varying length and/or intensity may evoke different cell outcomes depending upon the integrity of cell cycle control genes.
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Transplantation experiments of typical reef sponges to mangrove roots revealed that reef species deteriorated quickly after transplantation to coastal mangrove roots (Farnsworth and Ellison 1996; Wulff 2004; Pawlik et al. 2007), where the root substrate is critically important in limiting survival of reef species in mangrove systems (Hunting et al. 2013), while mangrove species remain unaffected.
We studied hematopoiesis at various stages of development as permitted by the limiting survival of STAT5abnull/null mice and found that Gab2 has functions that are non-redundant with STAT5 in controlling HSC survival and self-renewal.
The rapid dephosphorylation of Stat3 that occurs following UVB would serve to increase susceptibility to UVB-mediated apoptosis and thereby limit survival of keratinocytes with DNA damage that could lead to mutations and cancer development.
We found that high light triggers pathogenicity of the fungus, while low light favors endosymbiotic development, constraining recruitment of endophyte-infested seedlings to the shaded understory by limiting survival of seedlings in direct light, i.e., constraining the niche-space filling [4] of the otherwise highly successful I. deltoidea.
Nevertheless, their data suggest the existence of an upper limit of the mutation rate, beyond which negative clonal selection begins to limit survival of mutator clones.
The dysfunction of immune system such as decreased antigen presentation along with increased frequencies of suppressive cells and cytokines might facilitate progression of the disease and infectious complications limiting survival of MM patients.
Bmf has been implicated in apoptosis caused by loss of integrin signalling in certain cell types (Puthalakath et al, 2001) and hence may limit survival of HSPCs expelled from the niche.
Conversely, in the absence of wild-type MSH2, this damage persists and perhaps limits survival or at least fitness of cells, potentially explaining the MSH2 selectivity of methotrexate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com