Previous studies of primary HIV-1 infection have shown limited responsiveness to several HLA-A2-restricted CTL epitopes [54], [55], [56], [57], even though responses against the HIV Gag 77-85 (SL9, 77SLYNTVATL85) epitope becomes immunodominant in chronic infection [55], [56], [58].
Pain, overall health, falls/psychological factors, and total score of the JOQOL seem to have limited responsiveness to treatment changes.
What we dislike about the GX470 and other gone-soft truck-like SUVs is that these are big, powerful trucks and you need to know the limits of responsiveness just in case you have to swerve or brake quickly.
We note that the half lives of EGFP and EYFP are in the order of 24 h [55], limiting their responsiveness to fluctuations with timescales of less than one cell generation (∼15 h).
Sepsis-induced cardiac dysfunction may limit fluid responsiveness and the mechanism thereof remains unclear.
Indeed, right ventricular dysfunction caused by moderate pulmonary hypertension (which was not monitored in this study) has been described to limit fluid responsiveness before [ 6, 39].
Furthermore, the profile of other negative regulatory proteins is complex, and in theory could compensate for, or synergize with existing SOCS proteins to limit cytokine responsiveness in the cell.
In these mice, and consistent with the findings of Grossmann et al. 25, self-tolerance was found to limit the responsiveness of CD8+ T cells specific for each of the IDE when immunized with pΔTag (Fig. 2A cf. 1A).
23 It is also possible that altitude training interventions may increase Hbmass to a given individual's physiological limit, and responsiveness may therefore vary depending on an individual's baseline Hbmass.
This elongation is GA-dependent and its suppression by SUB1 is mediated by enhancement of (i) GA repressors SLR1 and SLR2, which limit GA responsiveness (Fukao and Bailey-Serres 2008; Bailey-Serres et al. 2010) and (ii) GA catabolism mediated by differential regulation of genes associated with brassinosteroid synthesis and the induction of a GA catabolism gene (Schmitz et al. 2013).
