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The strategy then is to treat intensely as soon as possible up to the limits of tolerability and then stop and hope that any microscopic tumors were eradicated.
Using this approach, we were able to increase the dose of oxaliplatin to 100 mg m−2 in an attempt to increase the efficacy of this regimen within the limits of tolerability.
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In preliminary studies, 3 min of upper arm blood flow occlusion at suprasystolic pressure was found to be the upper limit of tolerability.
Considering the limits of mexiletine tolerability and the occurrence of non-responders, this study proposes an arsenal of alternative drugs, which may prove useful to increase the quality of life of individuals suffering from non-dystrophic myotonia.
1, 3 Adverse effects related to their procholinergic mechanisms often limit the tolerability of these medications, with nearly a third of patients discontinuing treatment due to adverse effects such as nausea, vomiting, and diarrhea.
3. The 3 patient factors reported as most likely to make a DVT clinically important were clinical suspicion of PE, acute or chronic cardiopulmonary morbidity which might limit the tolerability of a PE, and leg symptoms.
Interpretation of tolerability correlations was therefore limited.
18, 19 The RFC is expressed both in tumor cells and normal tissue, 20 limiting the tolerability of antifolates.
However, advanced hepatic fibrosis may limit both the access as well as the response rates of patients to triple therapy with significant issues of tolerability and safety.
The issues of tolerability and especially the risk of tardive dyskinesia are not addressed in an 18-month study with a 75percentt dropout rate.
Analysis of tolerability was carried out in 123 patients.
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