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The statistical test results and limits of significance are depicted in Additional file 2: Table S2.
Only CPR shows a difference in the limits of significance.
A difference at the limits of significance was also observed in REE from 38°C to 36°C (2593 ± 228 kcal vs 2292 ± 434 kcal, P = 0.056).
Interestingly, however, while the joint swelling continued to progressively and spontaneously decrease in untreated AIA, it persisted in HA-treated animals after day 15, although the difference remained at the limits of significance (P = 0.06).
Some of the interleukins (IL-2, IL-3, IL-4 and IL-5) were expressed at low levels on both platforms and their fold change was at or near the limits of significance.
In cases in which P values for α were at the limits of significance (0.05 ≤ P ≤ 0.1; joint swelling day 29, cartilage damage day 8), the statistical power of the U test was determined using the actual difference at a given time point as delta.
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However, IL-1ra treatment showed only a little protection, and often the data were not significant or at the limit of significance, probably due to an insufficient dosage and a relatively long injection interval.
The third order interaction between main effects was never significant, although it was at the limit of significance for egg weight (P < 0.10).
Nevertheless, treatment with HYA alone showed less protection than that with C4S, and often the data were not significant (Fig. 2A,2B) or at the limit of significance (Figs 3C, 4, 5A,5B and 7).
CDV tended to be significantly higher in the diarrheic dogs than in the control dogs; although not significant, the P value was very close to the limit of significance (P = 0.059).
The multivariate analysis of OS showed TLs (High vs Low testosterone) to be in the limit of significance (HR: 0.6; CI95%: 0.4 1.0; P=0.0689) and anaemia (Yes vs No) to be a significant factor (HR: 1.9; CI95%: 1.0 3.5; P=0.046).
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CEO of Professional Science Editing for Scientists @ prosciediting.com