Suggestions(2)
Exact(1)
Evidence for efficacy at least to a pH in the region of 7.2 and to a core temperature of 34°C is growing, although it is likely that the limits of efficacy are somewhat lower.
Similar(59)
Table 1 Antibacterial effect assessment for different nanofiber membranes [82] Sample groups Bacteria growth Antibacterial activity Cotton gauze Moderate growth Insufficient effect PVA-crosslinked No growth Good effect PVA-Ag No growth Very good effect PVA-p-cospin Slight growth Limit of efficacy PAN No growth Good effect PAN-PEU No growth Good effect PVdF-HFP Heavy growth Insufficient effect.
Assuming a lower limit of efficacy of 48% and a regimen activity level of 68%, the study would proceed in two stages.
The reduction in HbA1c of 0·4 % was clinically significant, lying at the lower limit of efficacy expected for oral hypoglycaemic agents.
This reduction exceeds the clinically meaningful threshold of ≥0.3% proposed by the U.S. Food and Drug Administration for the development of new drugs for diabetes (29) and lies at the lower limit of efficacy expected for oral hypoglycemic agents (30).
Although there was a greater improvement in post-teaching MCQ among the simulator group, baseline scores were higher among lecture group which limits interpretation of efficacy.
Analogous to slow cooking, spore inactivation of spore-contaminated materials was tested using low temperatures and long times in order to explore the limits of sporicidal efficacy using hot, humid air.
Of course, the lack of a prognostically comparable control group limits the interpretation of efficacy importantly.
In fact, the lower limit of protective efficacy allowing to define IPTp-SP as a cost-effective intervention against maternal malaria was shown to be of 15% in this study.
When our model was evaluated at the lower limit of the efficacy parameters, the cost per life-year saved rose from $4,283 to $6,598 dollars+5454%), whereas at the upper limit, our cost-effectiveness ratio falls to $3,969 dollars (-7.3%) per life-year saved.
Thus, at the 6-week end point, our sample size was too limited for characterization of efficacy.
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Justyna Jupowicz-Kozak
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