In other words, nature's method of curing the disease is by producing scarring and fibrosis of the soft tissues sufficient to limit markedly external rotation.
However, clinical data are limited by markedly small sample sizes in some stage.
However, due to the delicate nature of the fruit, poor handling practices and inadequate storage facilities, the shelf life of the Chinese bayberry is still short, which markedly limits its market.
The resultant combination of systemic hypotension and vasoplegia blunts the normal redistribution of blood flow usually seen in circulatory shock and markedly limits the host's ability to sustain the vital organ blood flow.
In contrast to the genetic simplicity of STS in the first group, the biological and molecular diversity of complex karyotype STS markedly limits the identification of single and specific "oncogenic addiction" aberrations.
Furthermore, the variation in analytical practice markedly limits the value of Ki67 in this context.
If sunlight-avoidance is strictly followed, patients no longer suffer from phototoxicity, but the disease markedly limits outdoor-activities and activities in rooms lit by direct sunlight and thus, it affects social and working capabilities of the patients.
The patient often needs several re-operations, and if surgical debridement is not sufficient a Girdlestone situation is created; the patient then has to function without prosthesis for three to six months, which markedly limits physical activity.
Several proteins form the architecture of intercellular junctions in the endothelium, and among these, as shown in the present study, the tight junction adhesive protein JAM-A markedly limits MAB extravasation (reviewed in Weber et al, 2007).
The severity of NSAID-associated upper GI symptoms (pain, discomfort, or burning in the upper abdomen) was rated by the patient on daily diary cards on a 7-grade scale from 0 (none: no symptoms) to 6 (very severe: cannot be ignored and markedly limits daily activities and often requires rest).
