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The single-center nature of our study may be seen as a limitation, but it can also be a strength by limiting variability in patient management as different centers may have different protocols for fluid administration and use of diuretics and RRT.
All patients and controls originated from one defined geographical region of Russia and the great majority were ethnic Russians – thus limiting variability.
However, our method allowed a better control of the amount of O2 absorbed in the lungs, thus limiting variability in oxygenation parameters.
Relying primarily on WHO data also has the benefit of limiting variability associated with incorporating data from differently designed studies.
However, all centres were members of the French Pulmonary Arterial Hypertension Network, which comprises expert university pulmonary vascular centres that are familiar with these tests, and all followed standardised protocols, 23 thereby limiting variability among centres.
However, in the search for clinically relevant mtDNA variants, it is useful to rule out those evolutionary fixed, thus limiting variability analyses to few variants, annotated with estimation of conservation and prediction of pathogenicity, to obtain a shortlist of candidates that affect function of the gene/protein.
Similar(6)
Plant abiotic resistance in cultivated species features limited variability.
Simulated bone specimens limit variability and can replicate normal and osteoporotic bone.
For the purposes of our investigation, absolute gray values were chosen to limit variability in selection of the seed voxel gray value.
The same absolute gray value range was selected as in the second protocol to limit variability between methods for each tooth.
This same threshold value was used in all protocols to assess the particular tooth of interest to limit variability between methods.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com