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By the 1980s and 1990s, improvements in trial design, such as larger numbers of subjects, control of confounding risk factors, and limiting trial end points to those directly attributable to atherosclerotic events, were in place.
Conversely, limiting trial entry to those patients with disease duration less than a specified cutoff, for example 24 months, may eliminate those patients with longer disease duration and slower progression.
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Mr Straw has shown similar determination in his effort to limit trial by jury for petty criminals who, he argues, are "playing the system" very expensively.
13 Canagliflozin as a single agent has had limited trial data, and this is largely represented by one 26-week, randomized, placebo-controlled trial.
The potential of SDD to increase antibiotic resistance, despite being identified as a very important issue, would not necessarily limit trial participation.
The Revolutionary Tribunal was given the power to limit trials by asking jurors if their consciences had become "sufficiently enlightened" to pass death sentences before they knew all the facts.
Reuters also found that there was some evidence the company had already started limited trials with some merchants.
At first there will be limited trials, naturally: the Yara Birkeland will stay within 12 nautical miles of the Norwegian coast, shuttling between Larvik, Brevik and Herøya.
We noted that over 50% of trials were from North America and that there were limited trials exploring curricula for different ethnic groups.
As a reference, reported SBE rates ranged from 1 to 6% in the placebo arm of other recently completed clinical trials in severe sepsis [ 8, 10, 48]; however, SBE definitions may vary between trials, limiting inter-trial comparisons.
Instead, the authority is currently limiting the trial to one route, the X17J from Staten Island to Manhattan.
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