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Studies showed that the abnormality detection rate in enriched plasma cells (EPC) is greater than unselected plasma cells (UPC), but purification techniques are limiting to only FISH when sample volumes are inadequate.
Therefore the FatiScan gene enrichment test, which incorporates all transcriptional data rather than limiting to only significantly differentially expressed probes was used to analyse the transcriptional profile immediately after exercise [ 56].
From 504 GPS files, we obtained 383 sampling days of participant data (54 participants of the total of 57) after limiting to only those meeting the inclusion criteria (>70% complete GPS and temperature data).
However, in sensitivity analyses, limiting to only HD studies which could significantly reduce heterogeneity among the included studies, HD appeared to increase CI-AKI risk (RR 1.61; 95% CI, 1.13 2.28) but had no effect on the need for permanent RRT or progression to end-stage renal disease (RR 1.47; 95% CI, 0.56 3.89) [ 51] (Table 4).
For clarity, we will explain our method by limiting to only one motif in the sample, and every sequence contains at least one occurrence d-mutant of the motif even though our method can deal with multiple motifs and 10-20% of contamination.
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