Sentence examples for limiting their efficacy from inspiring English sources

As a result, they often localize to areas around the vessels from which they extravasate, never reaching the deep-seeded tumor cells, thereby limiting their efficacy.

Currently available influenza vaccines typically fail to elicit/boost broadly neutralizing antibodies due to the mutability of virus sequences and conformational changes during protective immunity, thereby limiting their efficacy.

Topical agents may interfere with activation of these TFs in psoriasis, but may also have off-target effects limiting their efficacy (e.g., corticosteroids) [8,9].

The conventional chemotherapeutic agents used in the treatment of human malignancies are directed nonspecifically against both malignant and nonmalignant cells, often limiting their efficacy with having serious side effects.

Although mTOR inhibitors prolong progression-free survival in patients with advanced RCC, most patients develop resistance to mTOR-inhibiting agents, limiting their efficacy; the new frontier of inhibiting the mTOR pathway is to identify agents targeting the feedback loops and crosstalks with other pathways involved in the acquired resistance to mTOR inhibitors.

Many of these treatments could induce left ventricular dysfunction (LVD), and limit their efficacy.

HIV-1 PR inhibitors (PIs) are used in combination antiviral therapy but the emergence of drug resistance has limited their efficacy.

Every branch of the federal government has become involved in attempts to limit their efficacy: President Obama has issued Executive Orders on the issue; several patent reform bills are being debated in Congress; and the Supreme Court will hear a record number of patent cases in the 2014 term.

However, development of resistance limits their efficacy in patients.

Hence, by inducing MCL1, HDACi could potentially, by themselves, limit their efficacy.

Bone grafts with growth factors also have shortcomings and problems that limit their efficacy.