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Indeed, larger clusters of microspheres might be stuck within larger arterioles, limiting the mean absorbed dose to finer liver structures, such as within the liver lobules.
Major toxicities were haematological, limiting the mean relative dose intensity of gemcitabine to 75%.
There is some evidence, based on an analysis of both Hodgkin's lymphoma and testicular cancers, that second cancer risks can be reduced by limiting the mean organ radiation dose (van den Belt-Dusebout et al, 2009).
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This is partly due to high levels of cloud cover, which limit the mean number of sunshine hours per day to between four and six.
However, the self-shadowing effect limited the mean size of the nanohelices.
However, drug resistance eventually emerges which limits the mean duration of response.
This language operates to limit the means by which a firm may lawfully either acquire or perpetuate monopoly power.
When he began his nursing career, clinical opportunities were limited – the means to advancement lay mainly in management or education.
"That is a watershed -- the first state law to limit the means of keeping animals in agriculture, and it won't be the last," Mr. Pacelli said.
Hence the combinatorial explosion of debates and deliberations, then as now, however limited the means of deliberation at the onset.
Achieving the goal of limiting the global mean temperature increase to two degrees Celsius will require nations to cut carbon emissions by 50% by 2050.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com