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At higher doses, its agonist effects plateau and it begins to behave more like an antagonist, limiting the maximal analgesic effect and respiratory depression.
Additionally the model complexity can be controlled by the user via limiting the maximal number of coefficients and the order of products of the basis functions.
None of the patients received a dose higher than 60 mg due to guidelines in place limiting the maximal dose.
In contrast, Ptc2 and Ptc3 seem to have more of a subsidiary role of limiting the maximal activity of Hog1 during activation (Young et al. 2002).
This leads to a much more appealing visualization as it allows limiting the maximal angular length of jump edges to <180○.
By limiting the maximal residual structural similarity according to the CATH classification (Pearl et al., 2003), TESE allows the user to generate ad hoc non-redundant sets of proteins with known structure.
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It was decided, in order to have a good match with the limited length variations of the available AMS devices (the initial maximal stent length was 15 mm; later, 20-mm-long stents also became available) and to have each lesion covered by maximally one stent, to limit the maximal lesion length to 15 mm initially and to 20 mm later.
The aging process, which researchers sometimes call "primary" or "intrinsic" aging, refers to the damage that ordinarily accumulates in our cells as we grow older, a natural condition that seems to have limited the maximal lifespan of humans to 120 years.
The lower jaw ligaments serve to limit the maximal extension of the mandibula.
An Esaki diode, vertically integrated to the transistor, limits the maximal emitter current density.
Being limited by the observational conditions, the accuracy of the observed result was limited, the maximal accidental error was about 6" and there existed certain systematic errors.
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