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Murine models of C.jejuni infection are typically viewed as colonization rather than disease models, thereby limiting the generation of new knowledge regarding host responses to this pathogen [11] [14].
Since it has previously been shown that carbenoxelone prevents EDH by limiting the generation of EDH itself [50], it is unlikely that the reduced smooth muscle hyperpolarization observed in the present study is due to altered cellular coupling, but rather to non-gap junction channel, receptor and/or store effects of this inhibitor [50], [51].
This suggests that Notch restricts neurogenesis by limiting the generation of NPCs.
In addition to complex I, Nrf2 deficiency may also affect complex II-dependent respiration by limiting the generation of FADH2.
For example, overstimulation of NK cells results in a reduced CD8 T-cell response limiting the generation of functional memory CD8 T cells.
This could reflect the known role of the actin cytoskeleton in limiting the generation of microtubule-based protrusions as previously described in Drosophila cells in culture [ 11].
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Those conditions limit the generation of fracture network.
However, technical difficulties such as harsh selection conditions and extensive screening processes to identify suitably responsive clones limit the generation of stable cell lines.
It has been reported that the use of microwave heating is beneficial for 3-acetylcoumarin synthesis, allowing for low catalyst loadings and short reaction times to limit the generation of unwanted side products [33, 34].
In addition, to limit the generation of more debris and to reduce costs further, it is likely that an ADR mission will aim to remove more than one debris object.
The receptor specificity of the viral HA is believed to be a factor that may limit the generation of human pandemic viruses from avian precursors [38].
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