Low compliance due to side-effects was seen as limiting the effectiveness of bupropion, attributed to smokers discontinuing the treatment.
However, accumulation of systemically administered drug in the brain is minimal due to the BBB, limiting the effectiveness of the treatment and increasing adverse side effects.
Obesity may also be limiting the effectiveness of statins.
These can be attacked using pulses of laser light, but skin obscures the tumour and absorbs some of the light, limiting the effectiveness of the treatment.
Left tackle Lomas Brown had an especially good game, limiting the effectiveness of Philadelphia's defensive end Hugh Douglas, who came into the game leading the league in sacks.
The goal will be to study the ways an athlete's shape affects performance -- like whether a breast stroke kick produces a lot of turbulence areas, or vortices, limiting the effectiveness of a swimmer's "pulling surfaces".
The White Ribbon campaign to end violence against women was already having a problematic February; campaign "ambassador" Tanveer Ahmed announced in the Australian that feminism itself was limiting the effectiveness of anti-violence campaigns because it was a "cult of victimhood" focused on "male villainy".
Additionally, traumatic tissues have a compromised blood supply, further limiting the effectiveness of systemic antibiotics.
Formation of this rind hindered contact between the permanganate and the DNAPL, limiting the effectiveness of the remediation.
Frequency-hopping (FH) signals [24, 25], similarly to OFDM, change spectral composition at each PRI, thus limiting the effectiveness of DRFM jammers.
For instance Facebook does not always offer meaningful checks on issue-based political advertising because, in some markets, it narrowly draws the definition as related to parties and candidates only, thereby limiting the effectiveness of the policy.
