Polypills improve adherence, are generally well tolerated, and reduce risk factor levels, although heterogeneity limits the certainty of the effect on risk factors.
Lastly, the cross-sectional nature of this analysis limits the certainty of inferences regarding the observed temporal-and dredging-associated differences in serum PCB levels.
Second, the small number of patients in each treatment group, especially in the insulin group, limited the certainty with which we could formulate conclusions regarding aspirin's effect.
The retrospective nature, small patient population, short follow-up duration, and inadequate definition of new-onset diabetes mellitus limit the certainty of our conclusions.
The young people of this country, to whom I dedicated the book, have limited job prospects, the certainty of debt, housing that may be beyond their means for a lifetime and, if pensions and the NHS progress as at present, no chance of a secure old age.
Some limitations affected the certainty of the present findings.
This also provides certainty and confidence to the market by limiting the volatility of permit prices.
They were limits which Alexis highlighted and exploited in their work, and limits which they rejected, along with the certainty of fixed gender identity and other kinds of black-and-white thinking.
Severe PPH risk was 2.5 times higher (95% CI 0.3 to 18.9) in women who used LMWH compared with those who did not, although the certainty of this estimate is limited by the small number of individuals in this stratum.
The available body of evidence for most drug classes was limited in quality and quantity, confining the range and the certainty of our conclusions.
