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The heterogeneity and rarity of infant ALL is the major limitation for clinical trials, resulting in slow accrual over long time periods and limiting study power.
Tūranga projects are expected to produce results quickly thus limiting study design.
However, limiting study data to those available at the moment of treatment decision might be more relevant for clinical practice.
Analysis has tended to be based on changes in diagnostic status rather than anges in symptom levels, limiting study power.
They have evolved to survive and function in this environment, the complexity of which represents a major obstacle limiting study of this protein class.
18, 19 The aim of this systematic review was to re-examine the association between low birthweight and adverse outcomes, avoiding the confounding influence of prematurity, by strictly limiting study inclusion to infants of 37 weeks' gestation or more.
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She was there, she said, to try to draw public attention to Lukashenko's assault on higher education, including limiting study-abroad programs and even trips, which now must be approved by the Ministry of Education.
However, determination of PI by Ki-67 IHC is subject to interobserver variation limiting study-to-study comparison (R. Schaffel et al., unpublished data) [ 23].
Spatial restrictions were also applied, limiting studies to Canada.
There has been limited study of trace elements and endometriosis.
Likewise, the small sample size of the present study also limits study generalizability.
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