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Yale biomedical engineers work to develop alternate strategies for drug delivery, based on physical targeting, or placement of the delivery system at the target site, limiting its activity to that site.
Yale biomedical engineers are at the cutting edge of solving this problem with an alternate strategy for drug delivery, which is based on physical targeting, or placement of the delivery system at the target site, limiting its activity to that site.
Perhaps the additional 50 amino acids in the Lpat521 construct interfere with substrate binding, limiting its activity in vivo.
We finally speculated that macroautophagosome formation/function may contribute to cell survival of Tzb-naive HER2-positive breast cancer cells challenged to Tzb at first, thus limiting its activity and promoting further resistance.
FGFR3 activation concurrently contributes to cell survival of Ctx-naive EGFR ligands-positive SCC tumour cells challenged to Ctx at first, thus limiting its activity and likely promoting their own resistance if Ctx-induced blockade of EGFR-ligands signalling persists.
On the other hand, differences may rest on a decreased stability of the chemical compound in a biological environment and/or to its capture or neutralization by chondrocyte-secreted proteins or macromolecules, thus limiting its activity.
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The financial sector in the U.S. has always immunized itself against basic change with the argument that limiting its activities is unthinkable because the economy needs an ever-growing financial sector to grow the whole economy.
The Society continued to exist in Berlin, limiting its activities mostly to a press campaign and rhetoric, but its meaning was seriously limited.
The TAp73 α isoform has been shown to contain an inhibitory domain that limits its activity, making it less efficient than other isoforms.
However, its pharmacological properties are not optimal: bosentan's moderate affinity and fast dissociation kinetics13,19,20 both limit its activity in vivo.
DealBook » Goldman Sets Up Fund to Invest in Risky Debt | Goldman Sachs "registered a fund that invests in risky credit products as a publicly traded business development company, a way for the bank to avoid some regulations that would otherwise limit its activity," Reuters reports.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com