Exact(4)
However, it is difficult to use in vitro dissolution results to predict in vivo dissolution, particularly the pH-dependent solubility of weak acid and base drugs, because the USP apparatus contains one vessel with a fixed pH for the test drug, limiting insight into in vivo drug dissolution of weak acid and weak base drugs.
However, in order to avoid confounding effects from the estrus cycle, these are typically carried out using males only, limiting insight into potential sex differences.
Faithful and tractable mouse models for t(8 21 -associated human acute myeloid leukaemia (AML) have been difficult to develop, limiting insight into the malignancy associated with this frequent chromosomal translocation.
Compounding these difficulties, experimental mouse models are lacking and diseased tissue for experimental analyses is typically obtained from patients with advanced disease at joint replacement surgery, thereby limiting insight to late stages of disease.
Similar(56)
Advertisers also have difficulty identifying new prospective market segments to target because they have limited insight into the desires and reactions of consumers.
Traditionally, manufacturers have had limited insight into how customers use the products they make, says Duncan Ross, director of data science at Teradata, the big data analytics specialist.
However, little research has been conducted in this area, which limits insight and understanding of the transplant failure experience that could subsequently inform clinical practice.
Two reports have provided important, yet limited, insight into the potential effectiveness of security cameras and partitions in reducing taxicab driver robberies and assaults (Stone and Stevens [1999]; Taxicab Advisory Group Committee 2004).
Over the past 140 years our understanding of the sedimentary architecture of the formation and its origins has remained in its infancy, which has limited insight into the evolution of the East Carpathian Foreland.
But it also acknowledged having limited insight into the regime's "precise motivation" for using chemical weapons, particularly at a moment when United Nations chemical-weapons inspectors were staying at a hotel just miles away.
Psychosis is a condition in which patients have limited insight.
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