To limit political hurdles, improvements to a building would be mandatory only if the energy audits showed that the costs of the improvements could be recouped through declines in energy bills within five years.
Many studies including the one by Lee et al. therefore studied moderate rather than severe injuries to limit the hurdles that must be overcome to achieve a favorable outcome.
Among the many contributing factors, manufacturing process induced parameter variations and lifetime operational-condition-dependent transistor aging are two major hurdles limiting the reliability of analog circuits.
Time and cost are among the most often cited hurdles limiting the rate and extent of adoption of Quality by Design (QbD) and Process Analytical Technology.
However, there are certain hurdles limiting their efficacious use in humans.
Poor high salt stress resistance remained as a main hurdle limiting the efficient bio-based succinic acid production.
For the majority of non-viral siRNA carriers studied so far, endosomal confinement is identified as the most prominent hurdle, limiting the full gene silencing potential.
One significant hurdle limiting clinical viability of tissue engineering is finding a way to stably vascularize the construct.
CDDP-based chemotherapy is an important treatment modality, and the development of chemoresistance is a major hurdle limiting successful treatment.
Thus, although enzymes such as lipases in particular have found extensive application in organic synthesis [ 7], effective stabilisation remains a technical hurdle limiting use of enzymes such as Pseudomonas lipases in industrial-scale biotransformations [ 8].
