However, although survivin is a protein that inhibits apoptosis and promote cell survival [66], silencing survivin failed to overcome TRAIL resistance in metastatic colon carcinoma cells, suggesting that Bcl-xL might be a limiting determinant of TRAIL resistance in the metastatic colon carcinoma cells.
While both protein catalytic hTERT and hTR subunits have been identified and cloned, the protein catalytic subunit is the limiting determinant of telomerase activity (Feng et al 1995; Meyerson et al 1997; Weinrich et al 1997; Counter et al 1998).
A plausible explanation for our observations implies that components of the auxin transport and/or signaling machinery represent rate-limiting determinants for plant morphogenesis.
MCT8 facilitates entry of thyroid hormones into target cells and is a rate-limiting determinant of intra-cellular thyroid hormone metabolism [29].
The expression of hTERT is the rate-limiting determinant of human telomerase activity (TA) and is thought to be a sensitive indicator of telomerase function and activity.
These observations of an associated response of PBGD and PPIX imply that PBGD may be a rate-limiting determinant for the efficacy of delta-ALA-induced photosensitization when used in photodynamic therapy.
The regulatory role of porphobilinogen deaminase in PpIX synthesis following ALA administration is considered the rate-limiting determinant and thus porphobilinogen deaminase is the key enzyme controlling photodiagnosis and photodynamic therapy (Gibson et al, 1998).
MEIS1 quantitatively regulates the differentiation arrest, cycling activity, in vivo progression, and self-renewal of MLL leukemia cells, thereby functioning as a critical and rate-limiting determinant of leukemia stem cell potential [ 16].
The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling.
The management of depression should include an appropriate diagnostic work up, especially to exclude organic or self-limiting determinants.
