Macromolecular drug carriers are an attractive alternative drug delivery method because they appear to target tumors and have limited toxicity in normal tissues.
For that reason it would have to have limited toxicity and, 0preferably, be orally available.
Such end-tagged peptides were found to display limited toxicity combined with high microbicidal potency of broad spectrum, also at physiological ionic strength and in the presence of serum, as well as ex vivo and in vivo.
FV-162 had limited toxicity and was well tolerated on a continuous daily dosing schedule.
The concentrations of BTBPE, which has limited toxicity data (see SI Table SI4), were similar between 2006 and 2011.
T-DM1, an antibody-drug conjugate, has also displayed remarkable activity in the setting of refractory disease and has limited toxicity.
We conclude that Aza can induce TI in severely anemic MDS patients, but efficacy is limited, toxicity substantial and most responses of short duration.
Compounds from garlic, such as diallyl disulfide (DADS), have been shown to have limited toxicity and reduce tumor load in vivo [ 6].
Unlike Fas ligand and TNF, TRAIL appears to have limited toxicity for mice and monkeys (Walczak et al, 1999), suggesting its potential value for cancer therapy.
Some of these chemicals have known biological activities, whereas most have limited toxicity data as compared to Phase I or have not been previously characterized.
Investigations on hard-metal disease have shown that either tungsten carbide or Co alone has limited toxicity on lung tissue (Lasfargues et al. 1992).
