Sentence examples for limited suppression of from inspiring English sources

Even then, viral infection and shRNA expression was limited to a small area around the injection site, resulting in spatially limited suppression of PrPC expression, modestly impeded disease progression and unaltered disease incidence.

While BRD4 inhibitors have shown some promise in MYC-driven malignancies such as Burkitt's lymphoma (BL), we show that BRD4 inhibitors lead to robust BRD4 protein accumulation, which may account for their limited suppression of MYC expression, modest antiproliferative activity, and lack of apoptotic induction.

While verapamil, nifedipine and diltiazem enhanced radiosensitivity at low doses and increased radioresistance at higher doses, flunarizine, which exhibits only limited suppression of cardiac contractility (Robertson and Robertson, 1996), increased radiosensitivity at all dose levels.

In summary, the observed induction of autophagy by both EtOH and INK128 combined with the dose dependent induction of apoptosis by INK128 but not by EtOH treatment further corroborates a limited suppression of mTOR by EtOH, as opposed to the potent mTOR inactivation by INK128 with respect to cellular phenotype and subsequent cell fate.

Thus it was observed in this work that suppression was reproducible, but a further assessment of whether limited suppression was reproducible and to what level of precision would need to be undertaken.

These findings may be explained by limited experimental suppression of LIN28B and MYCN, the fact that neither CH1 nor A2780 cell lines faithfully phenocopy all of the molecular defects seen C5 tumours, and the amplification of HMGA2 in CH1 cells.

It was speculated that metastatic OS cells express phosphorylated Ezrin only early after arrival in the lung, and this causes limited efficacy of suppression of Ezrin in readily established metastases, since its essential function in metastasis, namely connecting with the target organ site had already been fulfille [ 21].

Collectively, the results of the study suggest that, while the mitochondrial energetic function plays an important role in regulating the apoptotic process, its dysfunction has a limited influence on the suppression of apoptotic induction in OHCs following exposure to intense noise.

Moreover, these studies examined the suppression of a limited number of inflammatory mediators and so the true extent of Francisella's ability to antagonize TLR4 signaling is not known.

Furthermore, the rates of Cd accumulation were similar in short-term (0.11 pmol g fresh weight-1 h-1 for both isolines) and long-term (0.08 and 0.10 pmol g fresh weight-1 h-1 for TL-H and TL-L, respectively) experiments, suggesting that even after long exposure times (up to 60 h) there was limited efflux of Cd or suppression of Cd influx.

We reasoned that the inability to detect CLs was due in part to the ion suppression of the limited CL signals by other more abundant lipid ions such as phosphatidylcholine (PC) and further by the highly abundant and easily ionized carboxyl and amino groups of proteins and other lipids.