Many mechanisms have been suggested for this as well as ways to circumvent evolution of resistance in a previously exploitable pathway, including, but not limited to, substituting other PTK inhibitors or combining imatinib with other agents that affect other signal transduction steps.
The F.D.A. should declare that it no longer considers partially hydrogenated oil to be "generally recognized as safe" and give companies a limited time to substitute healthier oils.
And even then, the standards would provide limited incentives to substitute away from coal, the most carbon-intensive way to generate electricity.
While some may embrace the limited gains the substitute measure might provide, America deserves nothing less than the truly historic conservation financing that only the Conservation and Reinvestment Act would bring.
In this context, it is worth noting that V2b INs predominantly project their axons caudally and may therefore have a limited capacity to substitute for those V1 INs that have rostrally projecting axons.
Data presented in Figure 6C were obtained by Michaelis-Menten steady-state kinetics as in [ 36] in which all amino acids (excepting tyrosine because of its limited solubility) were substituted individually for cognate amino acids.
Results suggest that models with limited predictor pools can substitute other predictors to compensate for the missing variables.
They were both included in the team for the Sydney Olympics, although Bresciano only saw limited action as a substitute.
It is well known that polyalanine peptides are insoluble in aqueous solution, which led the Baldwin laboratory to develop many model helical peptides by substituting a limited number of ALA residues with polar amino acids [30], such as the ARG+ substitutions made in Fs.
When outfitted with clever peripherals like folding, full-size keyboards and snap-on modems, these pocket rockets can even do limited duty as lightweight substitutes for laptop computers.
